Question 1

What limits apply to psilocybin dose estimates?

Accepted Answer

No calculator can determine the right or safe amount for an individual. Product identity and potency, medications, health conditions, tolerance, and response vary, and body weight alone is not a reliable personal dosing rule. Any displayed ranges are general educational references rather than recommendations.

Question 2

Why does mushroom potency vary so much between strains?

Accepted Answer

Psilocybin content varies dramatically between strains due to genetics, growing conditions, harvest timing, and preparation. Average Psilocybe cubensis contains 0.6-1.2% total tryptamines, while high-potency strains (Penis Envy, Tidal Wave, Enigma) can contain 2-4%+. Panaeolus cyanescens averages 3-5% total tryptamines. Caps are often more potent than stems; first-flush mushrooms may differ from subsequent flushes. Always start low with any new strain or source.