Drug Interactions and Contraindications — SSRIs, MAOIs, Lithium, and Psychedelics

Critical safety guide for psychedelic drug interactions. SSRIs blunt psilocybin and LSD effects (serotonin tolerance). MAOIs combined with DMT or MDMA carry serious serotonin syndrome risk. Lithium combined with psychedelics increases seizure risk and is contraindicated. Full interaction profiles for antipsychotics, benzodiazepines, tramadol, and cardiovascular medications. The DMV's most comprehensive contraindication resource.