Question 1

What is psychedelic harm reduction?

Accepted Answer

Psychedelic harm reduction is a set of practical strategies to minimize risks associated with psychedelic use. Key principles include: starting with low doses, having a trusted trip sitter present, choosing a safe and comfortable environment (set and setting), testing substances when possible, avoiding mixing with other substances (especially MAOIs, SSRIs, and lithium), and having a plan for integration afterward.

Question 2

What should you not mix with psilocybin?

Accepted Answer

Psilocybin should not be mixed with lithium (risk of seizures), tramadol, or other serotonergic drugs without medical guidance. SSRIs and SNRIs may reduce psilocybin effects and carry theoretical serotonin syndrome risk. MAOIs can dangerously potentiate effects. Alcohol and cannabis can unpredictably alter the experience. Always consult a healthcare professional about potential interactions with any medications.

Question 3

What is a trip sitter?

Accepted Answer

A trip sitter is a sober, trusted person who remains present during a psychedelic experience to provide support, reassurance, and safety. Their role is not to guide the experience but to create a calm environment, help with practical needs, and intervene if the person becomes distressed. Trip sitting is considered one of the most important harm reduction practices.