Question 1

What is a typical mescaline dose?

Accepted Answer

Published references describe broad ranges for measured mescaline, but cactus preparations vary widely in identity and alkaloid concentration and cannot be converted reliably from length to dose. Reported ranges are descriptive, not recommendations or safety findings; onset, duration, interactions, and individual response also vary.

Question 2

Why does mescaline last so much longer than psilocybin?

Accepted Answer

Mescaline's duration of 8-14 hours (vs 4-6 hours for psilocybin) reflects its different pharmacokinetics. Mescaline is a phenethylamine alkaloid absorbed and metabolized more slowly, with a longer elimination half-life. Despite being a different chemical class, mescaline acts on the same 5-HT2A serotonin receptors as psilocybin and LSD, but its metabolism produces a more gradual, extended experience.